Polyclonal Anti-PCNA

CAT: 1510-BTL1035Size: 100 μgDry Ice: NoHazardous: No
CAT#:1510-BTL1035Size:100 μg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. It induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. And It has to be loaded onto DNA in order to be able to stimulate APEX2.
Host
Rabbit
Reactivity
Human, mouse, rat, monkey, Chinese hamster, dog
Immunogen
A synthetic peptide corresponding to internal residues of human PCNA.
Applications
Western Blot (1:5000-20000)
Form
Liquid
References & Citations
1. Bowman GD, O'Donnell M, Kuriyan J (2004) . "Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex". Nature 429 (6993) : 724–730. 2. Burkovics P., Hajdu I., Szukacsov V., Unk I., Haracska L."Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage." Nucleic Acids Res. 37:4247-4255 (2009) 3. Motegi A., Liaw H.-J., Lee K.-Y., Roest H.P., Maas A., Wu X., Moinova H., Markowitz S.D., Ding H., Hoeijmakers J.H.J., Myung K. "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks." Proc. Natl. Acad. Sci. U.S.A. 105:12411-12416 (2008)
Storage Conditions
Store at -20°C for 1 year. Avoid repeated freeze and thaw cycles.
Specificity
Detect the endogenous levels of total PCNA protein.

Related Products

CatalogName
BMA1034Monoclonal Anti- Proliferating Cell Nuclear Antigen, PCNA antibody
BTL1026Polyclonal Anti-β-Actin
BTL1031Polyclonal Anti- GAPDH antibody
BTL1034Polyclonal Anti-Lamin B
BTL1028Polyclonal Anti-Annexin A1
BTL1033Polyclonal Anti-Histone H3.1
BTL1032Polyclonal Anti-Histone H3.1
BDA1009Polyclonal Anti-NT-proBNP (Capture Ab)
BTL1006Polyclonal Anti-Green fluorescent protein, GFP antibody
BDA1046Monoclonal Anti-Ampicillin

Alternative Products

CatalogName
MF-0082517-01Anti-PCNA Polyclonal Antibody
MBS8101105-01Anti-PCNA Antibody, Rabbit Polyclonal
MF-0082518-01Anti-PCNA Polyclonal Antibody 2
HY337014-01Anti-Human PCNA Polyclonal Antibody
MBS2403274-01PCNA Rabbit anti-Human Polyclonal Antibody
AB1F073Anti-PCNA Ubiquitinated(K164) Polyclonal Antibody
MF-0087505-01Anti-Phosphos-PCNA (Tyr211) Polyclonal Antibody
MBS2403284-01PCNA Rabbit anti-Mouse Polyclonal Antibody
PAV5173Rabbit Anti-BACD3/PCNA Polyclonal Antibody
E20-73617PCNA Polyclonal Antibody

Popular Products