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Anti-VCP FITC

CAT: 0270-1F-300-T050Size: 50 TestsDry Ice: NoHazardous: No
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CAT#:0270-1F-300-T050Size:50 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VCP (valosin-containing protein), also known as p97, TERA, ALS14, IBMPFD, HEL-220, IBMPFD1, or HEL-S-70, is a member of a protein family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP is a structural protein that associates with clathrin and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. In sperm this intra-acrosomal protein can be used as a marker for evaluation of the physiological state of sperm cells as well as for selection of a suitable method of fertilization in the laboratories of assisted reproduction.
Certification
RUO
Reactivity
Mouse, Human
Immunogen
Freshly ejaculated human sperms were washed in PBS and extracted in 3% acetic acid, 10% glycerol, 30 mM benzaminidine. The acid extract was dialyzed against 0.2% acetic acid and subsequently used for immunization.
Target Antigen
VCP
Clone
Hs-14
Applications
FC (QC tested)
Format
FITC
Buffer
Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
References & Citations
*Tepla O. et al. In: In vitro Fertilization & Human Reproductive Genetics, ed. Monduzzi, Bologna, 107, (1999) ., URL: , *Chladek D, Peknicova J, Capkova J, Geussova G, Tepla O, Madar J: Use of human sperm protein monoclonal antibodies in the diagnosis of sperm pathology and selection of a suitable assisted reproduction method for fertilization. Ceska Gynekol. 2000 Jan;65 (1) :28-32. Czech., URL: https://www.ncbi.nlm.nih.gov/pubmed/10750294?dopt=, *Peknicova J, Chladek D, Hozak P: Monoclonal antibodies against sperm intra-acrosomal antigens as markers for male infertility diagnostics and estimation of spermatogenesis. Am J Reprod Immunol. 2005 Jan;53 (1) :42-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/15667524?dopt=
Other References
*Pavlásek J, Peknicová J, Ulcová-Gallová Z, Nováková P, Reischig J, Micanová Z, Rokyta Z: Significance of determination of intra-acrosomal proteins and sperm antibodies in human reproduction. Ceska Gynekol. 2004 Jul;69 (4) :306-11., URL: https://www.ncbi.nlm.nih.gov/pubmed/15369252?ordin, *Peknicova J, Kyselova V, Buckiova D, Boubelik M: Effect of an endocrine disruptor on mammalian fertility. Application of monoclonal antibodies against sperm proteins as markers for testing sperm damage. Am J Reprod Immunol. 2002 May;47 (5) :311-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/12148547?dopt=
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The antibody Hs-14 reacts with VCP (valosin-containing protein) a 220 kDa intra-acrosomal protein.
Applications Notes
6
Isotype
Mouse IgM

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