Anti-Hu CD106 Biotin

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Alternative Products

Cat	Name
MBS1801554-01	Anti-Hu CD106 Biotin
MBS1801554-02	Anti-Hu CD106 Biotin
MBS1801552-01	Anti-Hu CD106 Purified
MBS1801553-02	Anti-Hu CD106 APC
MBS1801555-01	Anti-Hu CD106 PE
MBS1801555-02	Anti-Hu CD106 PE
MBS1801553-01	Anti-Hu CD106 APC
MBS1801552-02	Anti-Hu CD106 Purified
E16FHB106-100U	Biotin anti-human CD106
MBS666648-02	anti-human CD106-Biotin

CAT:

270-1B-606-C100

Size:

0.1 mg

Price:

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For price, please contact [email protected].

Anti-Hu CD106 Biotin

Background: CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity. Soluble form of VCAM-1 (sVCAM-1) is an inflammatory marker and can be used also in prognosis of subsequent cariovascular events following acute coronary syndromes.
Specifications: The mouse monoclonal antibody STA recognizes an extracellular epitope of CD106 antigen (VCAM-1), a 100-110 kDa type I membrane protein of the immunoglobulin superfamily, a crucial mediator of leukocyte adhesion, and a costimulation molecule.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: Human DS6 T cell line
Target Antigen: CD106
Isotype: IgG1
Clone: STA
Applications: Flow cytometry: Recommended dilution: 5-6 μg/mL positive control: TNF-alpha activated HUVEC cells.
Validated Applications: FC, IP, IHC-F, ELISA
Concentration: 1 mg/mL
Format: Biotin
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995)., URL: ,*Leca G, Mansur SE, Bensussan A: Expression of VCAM-1 (CD106) by a subset of TCR gamma delta-bearing lymphocyte clones. Involvement of a metalloprotease in the specific hydrolytic release of the soluble isoform. J Immunol. 1995 Feb 1154(3):1069-77., URL: https://www.ncbi.nlm.nih.gov/pubmed/7529789?ordina,*Yen YT, Liao F, Hsiao CH, Kao CL, Chen YC, Wu-Hsieh BA: Modeling the early events of severe acute respiratory syndrome coronavirus infection in vitro. J Virol. 2006 Mar80(6):2684-93., URL: https://www.ncbi.nlm.nih.gov/pubmed/16501078?ordin,
Other References: *van Wetering S, van den Berk N, van Buul JD, Mul FP, Lommerse I, Mous R, ten Klooster JP, Zwaginga JJ, Hordijk PL: VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration. Am J Physiol Cell Physiol. 2003 Aug285(2):C343-52., URL: https://pubmed.ncbi.nlm.nih.gov/12700137/,*Wu TC: The role of vascular cell adhesion molecule-1 in tumor immune evasion. Cancer Res. 2007 Jul 167(13):6003-6., URL: https://pubmed.ncbi.nlm.nih.gov/17616653/,*Postadzhiyan AS, Tzontcheva AV, Kehayov I, Finkov B: Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and their association with clinical outcome, troponin T and C-reactive protein in patients with acute coronary syndromes. Clin Biochem. 2007 Sep 19, URL: https://pubmed.ncbi.nlm.nih.gov/18061588/,*Paessens LC, Singh SK, Fernandes RJ, van Kooyk Y: Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) provide co-stimulation in positive selection along with survival of selected thymocytes. Mol Immunol. 2008 Jan45(1):42-8., URL: https://pubmed.ncbi.nlm.nih.gov/17604837/,
Storage Conditions: Store at 2-8°C. Do not freeze.

Complementary Product Range

Our range of products, including Anti-Hu CD106 Biotin, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

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Find us on

Cat	Name
1B-606-C025	Anti-Hu CD106 Biotin
1B-606-C100	Anti-Hu CD106 Biotin
1P-606-T025	Anti-Hu CD106 PE
1A-606-T100	Anti-Hu CD106 APC
11-606-C025	Anti-Hu CD106 Purified
1P-606-T100	Anti-Hu CD106 PE
1A-606-T025	Anti-Hu CD106 APC
11-606-C100	Anti-Hu CD106 Purified
1B-207-C025	Anti-Hu CD8 Biotin
1B-208-C100	Anti-Hu CD9 Biotin