Products for Research Use Only
RegisterLogin

Anti-Hu CD148 APC

CAT: 0270-1A-697-T100Size: 100 TestsDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0270-1A-697-T100Size:100 Tests
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase, containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.
Certification
RUO
Reactivity
Human
Immunogen
Human recombinant CD148 (amino acids 1-444)
Target Antigen
CD148
Clone
MEM-CD148/05
Applications
FC (QC tested)
Format
APC
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Other References
*Stepanek O, Kalina T, Draber P, Skopcova T, Svojgr K, Angelisova P, Horejsi V, Weiss A, Brdicka T: Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. J Biol Chem. 2011 Jun 24;286 (25) :22101-12., URL: https://pubmed.ncbi.nlm.nih.gov/21543337/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody MEM-CD148/05 recognizes an extracellular epitope of CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosin phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.
Applications Notes
6
Isotype
Mouse IgG2b

Related Products

CatalogName
11-697-C025Anti-Hu CD148 Purified
1P-697-T025Anti-Hu CD148 PE
11-697-C100Anti-Hu CD148 Purified
1B-697-C100Anti-Hu CD148 Biotin
1P-697-T100Anti-Hu CD148 PE
1B-697-C025Anti-Hu CD148 Biotin
1A-274-T100Anti-Hu CD147 APC
1A-130-T100Anti-Hu CD142 APC
1A-274-T025Anti-Hu CD147 APC
1A-146-T100Anti-Hu CD184 APC

Alternative Products

CatalogName
MBS1801309-01Anti-Hu CD148 PE
MBS1801306-01Anti-Hu CD148 Purified
MBS1801308-01Anti-Hu CD148 Biotin
MBS1801307-01Anti-Hu CD148 APC
GTR18320624Mouse Hu CD148 Purified, clone MEM-CD148/05 (Monoclonal) Antibody
STJ96765Anti-CD148 antibody
114801A1-AATXFD750 Anti-human CD148 Antibody *MEM-CD148/05*
11480131-AATXFD350 Anti-human CD148 Antibody *MEM-CD148/05*
11480180-AATXFD680 Anti-human CD148 Antibody *MEM-CD148/05*
114801S0-AATPerCP Anti-human CD148 Antibody *MEM-CD148/05*

Popular Products