Anti-Hu CD105 APC

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MBS1801120-01	Anti-Hu CD105 PE
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MBS1801120-02	Anti-Hu CD105 PE
MBS1801125-01	Anti-Hu CD105 PE

Anti-Hu CD105 APC

CAT:

270-1A-298-T100

Size:

100 Tests

Price:

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For price, please contact [email protected].

Anti-Hu CD105 APC

Background: CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Specifications: The antibody MEM-226 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Certification: RUO
Host: Mouse
Species Reactivity: Rat, Human
Immunogen: Recombinant Vaccinia virus containing the human CD105 cDNA.
Target Antigen: CD105
Isotype: IgG2a
Clone: MEM-226
Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.
Validated Applications: FC
Format: APC
Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Schmidt D, Achermann J, Odermatt B, Breymann C, Mol A, Genoni M, Zund G, Hoerstrup SP: Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source. Circulation. 2007 Sep 11116(11 Suppl):I64-70., URL: http://www.ncbi.nlm.nih.gov/pubmed/17846327,*Asumda FZ, Chase PB: Age-related changes in rat bone-marrow mesenchymal stem cell plasticity. BMC Cell Biol. 2011 Oct 1212:44., URL: https://www.ncbi.nlm.nih.gov/pubmed/21992089 ,*Liang L, Zheng D, Lu C, Xi Q, Bao H, Li W, Gu Y, Mao Y, Xu B, Gu X: Exosomes derived from miR-301a-3p-overexpressing adipose-derived mesenchymal stem cells reverse hypoxia-induced erectile dysfunction in rat models. Stem Cell Res Ther. 2021 Jan 2512(1):87. , URL: https://pubmed.ncbi.nlm.nih.gov/33494812/,*Zhang J, Tang J, Liu J, Yan B, Yan B, Huang M, Zhang Z, Wang L: Melatonin promotes heterotopic ossification through regulation of endothelial-mesenchymal transition in injured achilles tendons in rats. Front Cell Dev Biol. 2021 Feb 119:629274., URL: https://pubmed.ncbi.nlm.nih.gov/33644068/,*Chang Y, Ben Y, Li H, Xiong Y, Chen G, Hao J, Ma X, Gao X, Qiang P, Shimosawa T, Wang X, Yang F, Xu Q: Eplerenone prevents cardiac fibrosis by inhibiting angiogenesis in unilateral urinary obstruction rats. J Renin Angiotensin Aldosterone Syst. 2022 Sep 172022:1283729. , URL: https://pubmed.ncbi.nlm.nih.gov/36185701/,
Other References: *Zhu Y, Sun Y, Xie L, Jin K, Sheibani N, Greenberg DA: Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells. Stroke. 2003 Oct34(10):2483-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/12947156?ordin,*Li C, Issa R, Kumar P, Hampson IN, Lopez-Novoa JM, Bernabeu C, Kumar S: CD105 prevents apoptosis in hypoxic endothelial cells. J Cell Sci. 2003 Jul 1116(Pt 13):2677-85., URL: https://www.ncbi.nlm.nih.gov/pubmed/12746487?ordin,*Guo B, Slevin M, Li C, Parameshwar S, Liu D, Kumar P, Bernabeu C, Kumar S: CD105 inhibits transforming growth factor-beta-Smad3 signalling. Anticancer Res. 2004 May-Jun24(3a):1337-45., URL: https://www.ncbi.nlm.nih.gov/pubmed/15274293?ordin,*Warrington K, Hillarby MC, Li C, Letarte M, Kumar S: Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells. Anticancer Res. 2005 May-Jun25(3B):1851-64., URL: https://www.ncbi.nlm.nih.gov/pubmed/16158917?ordin,*Piao M, Tokunaga O: Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study. J Atheroscler Thromb. 2006 Apr13(2):82-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/16733295?ordin,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

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1P-298-T025	Anti-Hu CD105 PE
1P-298-T100	Anti-Hu CD105 PE
1B-453-C025	Anti-Hu CD105 Biotin
1B-453-C100	Anti-Hu CD105 Biotin
1A-298-T100	Anti-Hu CD105 APC
1F-298-T025	Anti-Hu CD105 FITC
1F-453-T100	Anti-Hu CD105 FITC
11-298-C025	Anti-Hu CD105 Purified
1F-453-T025	Anti-Hu CD105 FITC
1A-453-T100	Anti-Hu CD105 APC