Products for Research Use Only
RegisterLogin

Anti-Hu CD34 APC

CAT: 0270-1A-297-T100Size: 100 TestsDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0270-1A-297-T100Size:100 Tests
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present on many stem cell populations. It is a well established stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions.
Certification
RUO
Reactivity
Human
Immunogen
Permanent human cell line derived from peripheral leucocytes of a patient suffering from chronic myeloid leukaemia.
Target Antigen
CD34
Clone
4H11[APG]
Applications
FC (QC tested)
Format
APC
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Elknerová K, Lacinová Z, Soucek J, Marinov I, Stöckbauer P: Growth inhibitory effect of the antibody to hematopoietic stem cell antigen CD34 in leukemic cell lines. Neoplasma. 2007;54 (4) :311-20., URL: http://www.ncbi.nlm.nih.gov/pubmed/17822321?itool=
Other References
*Krauter J, Hartl M, Hambach L, Kohlenberg A, Gunsilius E, Ganser A, Heil G: Receptor-mediated endocytosis of CD34 on hematopoietic cells after stimulation with the monoclonal antibody anti-HPCA-1. J Hematother Stem Cell Res. 2001 Dec;10 (6) :863-71., URL: http://www.ncbi.nlm.nih.gov/pubmed/11798512?ordina, *Dao MA, Arevalo J, Nolta JA: Reversibility of CD34 expression on human hematopoietic stem cells that retain the capacity for secondary reconstitution. Blood. 2003 Jan 1;101 (1) :112-8., URL: http://www.ncbi.nlm.nih.gov/pubmed/12393633?ordina, *Gangenahalli GU, Singh VK, Verma YK, Gupta P, Sharma RK, Chandra R, Gulati S, Luthra PM: Three-dimensional structure prediction of the interaction of CD34 with the SH3 domain of Crk-L. Stem Cells Dev. 2005 Oct;14 (5) :470-7., URL: http://www.ncbi.nlm.nih.gov/pubmed/16305332?ordina, *Gangenahalli GU, Singh VK, Verma YK, Gupta P, Sharma RK, Chandra R, Luthra PM: Hematopoietic stem cell antigen CD34: role in adhesion or homing. Stem Cells Dev. 2006 Jun;15 (3) :305-13., URL: http://www.ncbi.nlm.nih.gov/pubmed/16846369?ordina
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody 4H11[APG] reacts with extracellular class III epitope on CD34, a 110-115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells; it is gradually lost on progenitor cells. The antibody 4H11[APG] completely blocks binding of class III antibodies BIRMA K3 and 8G12 on KG1a cell line.
Applications Notes
6
Isotype
Mouse IgG1

Related Products

CatalogName
1P-566-T025Anti-Hu CD34 PE
1F-566-T100Anti-Hu CD34 FITC
1P-297-T100Anti-Hu CD34 PE
1P-664-T100Anti-Hu CD34 PE
1B-297-C100Anti-Hu CD34 Biotin
PC-566-T100Anti-Hu CD34 PerCP
11-664-C025Anti-Hu CD34 Purified
1F-297-T100Anti-Hu CD34 FITC
1F-664-T100Anti-Hu CD34 FITC
PC-664-T100Anti-Hu CD34 PerCP

Alternative Products

CatalogName
MBS1802476-01Anti-Hu CD34 APC
MBS1800244-01Anti-Hu CD34 FITC
MBS1802477-01Anti-Hu CD34 Biotin
MBS1800246-01Anti-Hu CD34 PerCP
MBS1800245-01Anti-Hu CD34 PE
MBS1800212-01Anti-Hu CD34 Purified
MBS1802481-01Anti-Hu CD34 PE-Cy5
MBS1802480-01Anti-Hu CD34 PE-Cy7
MBS1802220-01Anti-Hu CD34 PE-DyLight594
MBS1801964Anti-Hu CD34 Alexa Fluor488

Popular Products