Anti-CD3 epsilon (activation epitope) Purified

• Clone:

  APA1/1

• Format:

  Purified

• Buffer:

  Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• References & Citations:

  *Risueño RM, van Santen HM, Alarcón B: A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection. Proc Natl Acad Sci U S A. 2006 Jun 20;103 (25) :9625-30., URL: http://www.ncbi.nlm.nih.gov/pubmed/16766661?itool=, *Alarcón B, Ley SC, Sánchez-Madrid F, Blumberg RS, Ju ST, Fresno M, Terhorst C: The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes. EMBO J. 1991 Apr;10 (4) :903-12., URL: http://www.ncbi.nlm.nih.gov/pubmed/1826255?itool=E, *Gil D, Schrum AG, Alarcón B, Palmer E: T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes. J Exp Med. 2005 Feb 21;201 (4) :517-22., URL: https://www.ncbi.nlm.nih.gov/pubmed/15728235?itool, *Risueño RM, Gil D, Fernández E, Sánchez-Madrid F, Alarcón B: Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses. Blood. 2005 Jul 15;106 (2) :601-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/15790785?itool, *Delgado P, Fernández E, Dave V, Kappes D, Alarcón B: CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection. Nature. 2000 Jul 27;406 (6794) :426-30., URL: https://www.ncbi.nlm.nih.gov/pubmed/10935641?itool, *Tailor P, Tsai S, Shameli A, Serra P, Wang J, Robbins S, Nagata M, Szymczak-Workman AL, Vignali DA, Santamaria P: The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling. J Immunol. 2008 Jul 1;181 (1) :243-55., URL: https://pubmed.ncbi.nlm.nih.gov/18566390/, *Rieux-Laucat F, Hivroz C, Lim A, Mateo V, Pellier I, Selz F, Fischer A, Le Deist F: Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. N Engl J Med. 2006 May 4;354 (18) :1913-21., URL: https://www.ncbi.nlm.nih.gov/pubmed/16672702?itool, *Torres PS, Alcover A, Zapata DA, Arnaud J, Pacheco A, Martín-Fernández JM, Villasevil EM, Sanal O, Regueiro JR: TCR dynamics in human mature T lymphocytes lacking CD3 gamma. J Immunol. 2003 Jun 15;170 (12) :5947-55., URL: https://www.ncbi.nlm.nih.gov/pubmed/12794121?itool, *Wong AP, Dutly AE, Sacher A, Lee H, Hwang DM, Liu M, Keshavjee S, Hu J, Waddell TK: Targeted cell replacement with bone marrow cells for airway epithelial regeneration. Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293 (3) :L740-52., URL: https://www.ncbi.nlm.nih.gov/pubmed/17616650?itool

• CAS Number:

  9007-83-4