Anti-GRB2 Purified

CAT: 0270-11-554-C100Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0270-11-554-C100Size:0.1 mg
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Description
Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.
Certification
RUO
Reactivity
Human
Immunogen
Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217) .
Target Antigen
GRB2
Clone
PAb (554)
Applications
WB
Concentration
1 mg/mL
Format
Purified
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Other References
*Sieh M, Batzer A, Schlessinger J, Weiss A: GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol Cell Biol. 1994 Jul;14 (7) :4435-42., URL: https://www.ncbi.nlm.nih.gov/pubmed/7516467?ordina, *Reif K, Buday L, Downward J, Cantrell DA: SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. J Biol Chem. 1994 May 13;269 (19) :14081-7., URL: https://www.ncbi.nlm.nih.gov/pubmed/8188688?ordina, *den Hertog J, Hunter T: Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains. EMBO J. 1996 Jun 17;15 (12) :3016-27., URL: https://www.ncbi.nlm.nih.gov/pubmed/8670803?ordina
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The polyclonal antibody recognizes Grb2, a highly conserved approximately 26 kDa intracellular adaptor protein. The immunogen has 100% identity between man, cow, rat and mouse.
Applications Notes
Western blotting: Recommended dilution: 1-2 μg/ml, reducing conditions.
Isotype
Rabbit polyclonal

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