6-O-Desmethyl donepezil

• UNSPSC Description:

  6-O-Desmethyl donepezil is the metabolite of Donepezil (HY-14566). 6-O-Desmethyl donepezil is an inhibitor for hERG channel with an IC50 of 1 μM[1].

• Target Antigen:

  Drug Metabolite; Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/6-o-desmethyl-donepezil.html

• Smiles:

  O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(O)C(OC)=C4

• Molecular Weight:

  365.47

• References & Citations:

  [1]Chae YJ, et al., Effects of donepezil on hERG potassium channels. Brain Res. 2015 Feb 9;1597:77-85.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  120013-56-1