Anti-Hu IgM Purified

• Description:

  Immunoglobulin M (IgM) is produced as a 900 kDa pentamer, which is an efficient complement binder. This antibody type is produced initially in the immune response and it is the first immunoglobulin class to be synthesized by a fetus or newborn. IgM antibodies do not cross the placenta. IgM concentration in blood is 0.12 g/l and its biological survival (plasma T1/2) is 5 days.

• Certification:

  RUO

• Reactivity:

  Human

• Immunogen:

  IgM from human serum.

• Target Antigen:

  IgM

• Clone:

  MA2

• Applications:

  ELISA

• Concentration:

  1 mg/mL

• Format:

  Purified

• Buffer:

  Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

• References & Citations:

  *Maerle AV, Simonova MA, Pivovarov VD, Voronina DV, Drobyazina PE, Trofimov DY, Alekseev LP, Zavriev SK, Ryazantsev DY: Development of the covalent antibody-DNA conjugates technology for detection of IgE and IgM antibodies by immuno-PCR. PLoS One 2019 Jan 4;14 (1) :e0209860., URL: https://pubmed.ncbi.nlm.nih.gov/30608947/

• Other References:

  *Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh) . 1975;194:77-95., URL: https://www.ncbi.nlm.nih.gov/pubmed/47690?ordinalp, *Fuller JM, Keyser JW: Serum immunoglobulins after surgical operation. Clin Chem. 1975 May;21 (6) :667-71., URL: https://www.ncbi.nlm.nih.gov/pubmed/1122610?ordina, *Balogh Z, Merétey K, Falus A, Bozsóky S: Serological abnormalities in juvenile chronic arthritis: a review of 46 cases. Ann Rheum Dis. 1980 Apr;39 (2) :129-34., URL: https://www.ncbi.nlm.nih.gov/pubmed/6966908?ordina, *Brinkmann V, Heusser CH: T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors. Cell Immunol. 1993 Dec;152 (2) :323-32., URL: https://www.ncbi.nlm.nih.gov/pubmed/8258141?ordina

• Storage Conditions:

  Store at 2-8°C. Do not freeze.

• Specificity:

  The antibody MA2 reacts with µ -chain of human IgM, Fab - region localized epitope.

• Isotype:

  Mouse IgG2b