Anti-Hu CD273 Purified

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAT:

270-11-178-C100

Size:

0.1 mg

Price:

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Anti-Hu CD273 Purified

Background: CD273 / PD-L2 (programmed death ligand-1), also known as B7-DC, is a member of the B7 family of regulatory proteins. It costimulates the proliferation of T cells, and mediates IFN gamma production. Ligation of CD273 on dendritic cells enhances dendritic cell activation and T cell responses. When interacting with CD279, it can act as a coinhibitor of the T cell function. CD273 expression is a useful marker to distinguish primary mediastinal B cell lymphoma from other diffuse large B cell lymphomas.
Specifications: The mouse monoclonal antibody 24F.10C12 recognizes an extracellular epitope of CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin´s lymphoma cells and primary mediastinal B cell lymphoma (PMBL).
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: human CD273 cDNA
Target Antigen: CD273
Isotype: IgG2a κ
Clone: 24F.10C12
Applications: Flow cytometry: Recommended dilution: 1-4 µg/mL
Validated Applications: FC, IHC
Concentration: 1 mg/mL
Format: Purified
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, Chapuy B, Takeyama K, Neuberg D, Golub TR, Kutok JL, Shipp MA: Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010 Oct 28116(17):3268-77., URL: http://www.ncbi.nlm.nih.gov/pubmed/20628145,*Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG: Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr89(4):507-15., URL: https://pubmed.ncbi.nlm.nih.gov/21097698/,*Semnani RT, Mahapatra L, Moore V, Sanprasert V, Nutman TB: Functional and phenotypic characteristics of alternative activation induced in human monocytes by interleukin-4 or the parasitic nematode Brugia malayi. Infect Immun. 2011 Oct79(10):3957-65., URL: http://www.ncbi.nlm.nih.gov/pubmed/21788379 ,
Storage Conditions: Store at 2-8°C. Do not freeze.

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11-178-C025	Anti-Hu CD273 Purified
11-178-C100	Anti-Hu CD273 Purified
1P-178-T025	Anti-Hu CD273 PE
1P-178-T100	Anti-Hu CD273 PE
1A-178-T100	Anti-Hu CD273 APC
T7-178-T100	Anti-Hu CD273 PE-Cy1537
A6-178-T100	Anti-Hu CD273 Alexa Fluor® 647
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