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Aladorian

CAT: 0804-HY-119850-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119850-01Size:1 mg
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Description
Aladorian (ARM036) is a benzothiazepine derivative, with anti-arrhythmia effect. Aladorian is a ryanodine receptor (RyR2) blocker. Aladorian is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia[1][2][3].
CAS Number
865433-00-7
Product Name Alternative
ARM036
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aladorian.html
Purity
99.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(N1CCSC2=CC=C(C=C2C1)OC)=O)O
Molecular Formula
C12H13NO4S
Molecular Weight
267.30
Precautions
H302, H312, H332
References & Citations
[1]Thevis M, et al. Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls. J Pharm Biomed Anal. 2014 Dec;101:66-83.|[2]Luo M, et al. Mechanisms of altered Ca²⁺ handling in heart failure. Circ Res. 2013 Aug 30;113 (6) :690-708.|[3]Kupatt C, et al. Ryanodine Receptors Matter for Cardiac Function in Duchenne Muscular Dystrophy: Stability First. J Am Coll Cardiol. 2021 Dec 14;78 (24) :2454-2456.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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