Regorafénib N-oxyde (M2)
CAT:
804-HY-I0678-04
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Regorafénib N-oxyde (M2)
- CAS Number: 835621-11-9
- UNSPSC Description: Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.
- Target Antigen: Drug Metabolite; PDGFR
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/Regorafénib_N-oxyde_M2.html
- Purity: 99.32
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- Smiles: FC1=CC(OC2=CC=[N+]([O-])C(C(NC)=O)=C2)=CC=C1NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O
- Molecular Weight: 498.81
- References & Citations: [1]Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported