Olorofim

• Description :

  Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318) . Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp.[1].

• Product Name Alternative :

  F901318

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Dihydroorotate Dehydrogenase; Fungal

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/olorofim.html

• Purity :

  99.57

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC=C(N2CCN(C3=NC=C(F)C=N3)CC2)C=C1)C(C4=C(C5=CC=CC=C5)C=C(C)N4C)=O

• Molecular Formula :

  C28H27FN6O2

• Molecular Weight :

  498.55

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Lackner M, et al. Dihydroorotate dehydrogenase inhibitor olorofim exhibits promising activity against all clinically relevant species within Aspergillus section Terrei. J Antimicrob Chemother. 2018 Nov 1;73 (11) :3068-3073.|[2]du Pré S, et al., Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus. Antimicrob Agents Chemother. 2018 Jul 27;62 (8) :e00231-18.|[3]Seyedmousavi S, et al., Efficacy of Olorofim (F901318) against Aspergillus fumigatus, A. nidulans, and A. tanneri in Murine Models of Profound Neutropenia and Chronic Granulomatous Disease. Antimicrob Agents Chemother. 2019 May 24;63 (6) :e00129-19.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• CAS Number :

  [1928707-56-5]