10-Hydroxywarfarin

• UNSPSC Description:

  10-Hydroxywarfarin, a metabolite of (R)-(+)-Warfarin (HY-W015998 ), is a CYP2C9 and vitamin K epoxide reductase complex 1 (VKOR) inhibitor with IC50s of 1.6 µM and 80 ng/mL, respectively[1][2].

• Target Antigen:

  Cytochrome P450; Drug Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/10-hydroxywarfarin.html

• Smiles:

  O=C1C(C(C2=CC=CC=C2)C(O)C(C)=O)=C(O)C3=CC=CC=C3O1

• Molecular Weight:

  324.33

• References & Citations:

  [1]Shuhei Kobayashi, et al. Combination index of the concentration and in vivo antagonism activity of racemic warfarin and its metabolites to assess individual drug responses. J Thromb Thrombolysis. 2019 Apr;47(3):467-472. |[2]Drew R Jones, et al. Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. Chem Res Toxicol. 2010 May 17;23(5):939-45.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  83219-99-2