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10-Hydroxywarfarin

CAT: 0804-HY-134999-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134999-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
10-Hydroxywarfarin, a metabolite of (R) - (+) -Warfarin , is a CYP2C9 and vitamin K epoxide reductase complex 1 (VKOR) inhibitor with IC50s of 1.6 µM and 80 ng/mL, respectively[1][2].
CAS Number
83219-99-2
UNSPSC
12352005
Hazard Statement
H300-H318
Target
Cytochrome P450; Drug Metabolite; VKOR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/10-hydroxywarfarin.html
Smiles
O=C1C(C(C2=CC=CC=C2)C(O)C(C)=O)=C(O)C3=CC=CC=C3O1
Molecular Formula
C19H16O5
Molecular Weight
324.33
Precautions
P264-P270-P280-P305+P351+P338-P330-P405-P501
References & Citations
[1]Shuhei Kobayashi, et al. Combination index of the concentration and in vivo antagonism activity of racemic warfarin and its metabolites to assess individual drug responses. J Thromb Thrombolysis. 2019 Apr;47 (3) :467-472. |[2]Drew R Jones, et al. Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. Chem Res Toxicol. 2010 May 17;23 (5) :939-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2C9

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