10-Hydroxywarfarin

• Description :

  10-Hydroxywarfarin, a metabolite of (R) - (+) -Warfarin (HY-W015998), is a CYP2C9 and vitamin K epoxide reductase complex 1 (VKOR) inhibitor with IC50s of 1.6 µM and 80 ng/mL, respectively[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H300-H318

• Target :

  Cytochrome P450; Drug Metabolite; VKOR

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/10-hydroxywarfarin.html

• Smiles :

  O=C1C(C(C2=CC=CC=C2)C(O)C(C)=O)=C(O)C3=CC=CC=C3O1

• Molecular Formula :

  C19H16O5

• Molecular Weight :

  324.33

• Precautions :

  P264-P270-P280-P305+P351+P338-P330-P405-P501

• References & Citations :

  [1]Shuhei Kobayashi, et al. Combination index of the concentration and in vivo antagonism activity of racemic warfarin and its metabolites to assess individual drug responses. J Thromb Thrombolysis. 2019 Apr;47 (3) :467-472. |[2]Drew R Jones, et al. Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. Chem Res Toxicol. 2010 May 17;23 (5) :939-45.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CYP2C9

• CAS Number :

  [83219-99-2]