NF-κB/MAPK-IN-1

NF-κB/MAPK-IN-1

• CAS Number: 2413940-56-2
• UNSPSC Description: NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research[1].
• Target Antigen: COX; NF-κB; NO Synthase; p38 MAPK
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;MAPK/ERK Pathway;NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/nf-κb-mapk-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(NC1=CC=C(OC2=CC(OC)=CC=C2C(C)=O)C=C1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3
• Molecular Weight: 477.51
• References & Citations: [1]Hu YS, et al. Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo. Bioorg Chem. 2020 May;98:103735.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported