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(-) -CMLD010509

CAT: 0804-HY-119271ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119271ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -CMLD010509 ((-) -SDS-1-021) is an isomer of CMLD010509 (SDS-1-021). CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM) -including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism[1].
CAS Number
2240186-24-5
Product Name Alternative
(-) -SDS-1-021
UNSPSC
12352005
Target
Apoptosis; c-Myc
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/minus-cmld010509.html
Smiles
O[C@]12[C@](OC3=CC(OC)=CC(OC)=C32)(C4=CC=C(C=C4)Br)[C@H](C5=CC=CC=C5)[C@H]([C@H]1O)C(NOC)=O
Molecular Formula
C27H26BrNO7
Molecular Weight
556.40
References & Citations
[1]Manier S, et al. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10;9 (389) . pii: eaal2668.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19206191-01CMLD010509

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