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Recombinant Rat Eotaxin/CCL11

CAT: 0355-AP60380Size: InquireDry Ice: NoHazardous: No
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Background
CCL11 encoded by the gene CCL11is belonging to the CC chemokine family. It is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. CCL11 is a strong and specific eosinophil chemoattractant in vitro. It can directly chemotactic for eosinophils, but not for monocytes or neutrophils. CCR3 has been identified to be a specific CCL11 receptor. CCR3 has also been shown to serve as a cofactor for a restricted subset of primary HIV viruses and binding of CCL11 to CCR3 inhibited infection by the HIV isolates.
Product Name Alternative
Small-inducible Cytokine A11
Gene ID
29397
UniProt
P97545
Target
HPGSIPTSCC FTMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTKLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP
Purification
> 96 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ugof rRtEotaxin/CCL11 as determined by LAL method.
Bioactivity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using purified eosinophils is in a concentration range of 0.1-1.0 μg/ml.
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 8.4 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 150 mM NaCl.
Host or Source
Escherichia coli

UniProtKB · P97545

Eotaxin

CCL11_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
P97545
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Ccl11
Protein existence
3: Inferred from homology
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
O08780
Protein keywords

Biological process

ChemotaxisInflammatory response

Molecular function

Cytokine

PTM

Disulfide bondGlycoprotein

Technical term

Reference proteome

Cellular component

Secreted

Domain

Signal

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