Catharanthine (Standard)

• Description:

  Catharanthine (Standard) is the analytical standard of Catharanthine. This product is intended for research and analytical applications. Catharanthine ((+) -3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC) . Catharanthine has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR) . Catharanthine has anti-cancer activity[1][2].

• Product Name Alternative:

  (+) -3,4-Didehydrocoronaridine (Standard)

• UNSPSC:

  12352005

• Target:

  Calcium Channel; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling; Others

• Field of Research:

  Cancer; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/catharanthine-standard.html

• Smiles:

  O=C([C@@]12C3=C(CC[N@](C4)[C@]1([H])C(CC)=C[C@@]4([H])C2)C5=CC=CC=C5N3)OC

• Molecular Formula:

  C21H24N2O2

• Molecular Weight:

  336.43

• References & Citations:

  [1]Jadhav A, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345 (3) :383-92.|[2]Hugo R Arias, et al. (+) -Catharanthine and (-) -18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission. Eur J Pharmacol. 2023 Jan 15:939:175454.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [2468-21-5]