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Catharanthine (Standard)

CAT: 0804-HY-N0252R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0252R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Catharanthine (Standard) is the analytical standard of Catharanthine. This product is intended for research and analytical applications. Catharanthine ((+) -3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC) . Catharanthine has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR) . Catharanthine has anti-cancer activity[1][2].
CAS Number
2468-21-5
Product Name Alternative
(+) -3,4-Didehydrocoronaridine (Standard)
UNSPSC
12352005
Target
Calcium Channel; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/catharanthine-standard.html
Smiles
O=C([C@@]12C3=C(CC[N@](C4)[C@]1([H])C(CC)=C[C@@]4([H])C2)C5=CC=CC=C5N3)OC
Molecular Formula
C21H24N2O2
Molecular Weight
336.43
References & Citations
[1]Jadhav A, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345 (3) :383-92.|[2]Hugo R Arias, et al. (+) -Catharanthine and (-) -18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission. Eur J Pharmacol. 2023 Jan 15:939:175454.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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