Catharanthine

• Description :

  Catharanthine ((+) -3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC) . Catharanthine has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR) . Catharanthine has anti-cancer activity[1][2].

• Product Name Alternative :

  (+) -3,4-Didehydrocoronaridine

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Calcium Channel

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/catharanthine.html

• Concentration :

  10mM

• Purity :

  99.65

• Solubility :

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@]12C3=C(CC[N@](C4)[C@]1([H])C(CC)=C[C@@]4([H])C2)C5=CC=CC=C5N3)OC

• Molecular Formula :

  C21H24N2O2

• Molecular Weight :

  336.43

• Precautions :

  H302

• References & Citations :

  [1]Jadhav A, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345 (3) :383-92.|[2]Hugo R Arias, et al. (+) -Catharanthine and (-) -18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission. Eur J Pharmacol. 2023 Jan 15:939:175454.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  L-type calcium channel

• Citation 01 :

  Ind Crops Prod. 2025 Aug.|Cell Signal. 2025 Mar 29:111779.

• CAS Number :

  [2468-21-5]