Aminoadipic acid

• Description:

  Aminoadipic acid is an orally active lysine oxide derivative. Aminoadipic acid induces ROS generation, increases free Ca2+, decreases SOD, and activates TXNIP/NLRP3 pathway. Aminoadipic acid has pro-inflammatory effects. Aminoadipic acid can be used in atherosclerosis research[1][2][3][4].

• Product Name Alternative:

  YH439

• UNSPSC:

  12352211

• Hazard Statement:

  H317

• Target:

  Calcium Channel; Endogenous Metabolite; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS) ; SOD

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Aminoadipic_acid.html

• Purity:

  99.86

• Solubility:

  DMSO : 2 mg/mL (ultrasonic) |H2O : 2.86 mg/mL (ultrasonic)

• Smiles:

  O=C(O)C(N)CCCC(O)=O

• Molecular Formula:

  C6H11NO4

• Molecular Weight:

  161.16

• Precautions:

  H317

• References & Citations:

  [1]Wang TJ, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct;123 (10) :4309-17.|[2]Wang X, et al. α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension. Drug Des Devel Ther. 2016 Oct 20;10:3449-3457.|[3]Estaras M, et al. The lysine derivative aminoadipic acid, a biomarker of protein oxidation and diabetes-risk, induces production of reactive oxygen species and impairs trypsin secretion in mouse pancreatic acinar cells. Food Chem Toxicol. 2020 Nov;145:111594.|[4]Wang T, et al. Aminoadipic acid aggravates atherosclerotic vascular inflammation through ROS/TXNIP/NLRP3 pathway, a harmful microbial metabolite reduced by paeonol. Int J Biochem Cell Biol. 2024 Dec;177:106678.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  [542-32-5]