2,3,4,6,7,8-Hexachlorodibenzofuran

2,3,4,6,7,8-Hexachlorodibenzofuran

• CAS Number: 60851-34-5
• UNSPSC Description: 2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 2,3,4,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 0.687 and 0.575 nM, respectively)[1][2].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/2-3-4-6-7-8-hexachlorodibenzofuran.html
• Smiles: ClC1=C(Cl)C(Cl)=C(OC2=C(Cl)C(Cl)=C(Cl)C=C23)C3=C1
• Molecular Weight: 374.86
• References & Citations: [1]Harnly M, et al. Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Contamination at Metal Recovery Facilities, Open Burn Sites, and a Railroad Car Incineration Facility. Environ Sci Technol. 1995 Mar 1;29(3):677-84. |[2]Bandiera S, et al. Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology. 1984 Aug;32(2):131-44.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported