1,2,3,4,7,8-Hexachlorodibenzofuran

1,2,3,4,7,8-Hexachlorodibenzofuran

• CAS Number: 70648-26-9
• UNSPSC Description: 1,2,3,4,7,8-Hexachlorodibenzofuran (1,2,3,4,7,8-HxCDF) promotes the gene expressions of CYP1A1, CYP1B1, and aryl hydrocarbon receptor repressor (AhRR) in human peripheral blood lymphocytes (PBLs). 1,2,3,4,7,8-Hexachlorodibenzofuran activates the ethoxyresorufin-Odeethylase, achieves 20% of the maximum response caused by TCDD with a BMR20TCDD of 0.115-0.143 nM[1].
• Target Antigen: Aryl Hydrocarbon Receptor; Cytochrome P450
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/1-2-3-4-7-8-hexachlorodibenzofuran.html
• Smiles: ClC1=CC2=C(C=C1Cl)C3=C(Cl)C(Cl)=C(Cl)C(Cl)=C3O2
• Molecular Weight: 374.86
• References & Citations: [1]van Ede KI, et al., Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicol Lett. 2014 Apr 7;226(1):43-52.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported