Thalidomide-piperidine-C-Pip-C2-Pip-C2-OH

• UNSPSC Description:

  Thalidomide-piperidine-C-Pip-C2-Pip-C2-OH (Compound C6) is a conjugate of the linker and E3 ligase ligand, that can be used in synthesis of PROTAC PARP1 degrader-30 (HY-168722)[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates; PARP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-piperidine-c-pip-c2-pip-c2-oh.html

• Smiles:

  OCCC1CCN(CCC2CCN(CC3CCN(C4=CC5=C(C(N(C6CCC(NC6=O)=O)C5=O)=O)C=C4)CC3)CC2)CC1

• Molecular Weight:

  593.76

• References & Citations:

  [1]Wu M, et al., Discovery of a potent PARP1 PROTAC as a chemosensitizer for the treatment of colorectal cancer. Eur J Med Chem. 2025 Jan 15;282:117062.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported