Humanin

• UNSPSC Description:

  Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2].

• Target Antigen:

  Bcl-2 Family

• Type:

  Peptides

• Related Pathways:

  Apoptosis

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/humanin.html

• Purity:

  99.83

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C([C@H]1N(CCC1)C([C@H](C)NC([C@@H](N)CCSC)=O)=O)N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CO)C(N[C@@H](CS)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](C)C(O)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Weight:

  2687.23

• References & Citations:

  [1]Guo B, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003 May 22;423(6938):456-61. |[2]Muzumdar RH, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009 Jul 22;4(7):e6334.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  330936-69-1