(±)-cis-Sertraline-d3 (hydrochloride)

• UNSPSC Description:

  (±)-cis-Sertraline-d3 (hydrochloride) is the deuterium labeled Sertraline hydrochloride. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2].

• Target Antigen:

  Isotope-Labeled Compounds; Serotonin Transporter

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Neuronal Signaling;Others

• Field of Research:

  Neurological Disease

• Purity:

  99.54

• Solubility:

  DMSO : 50 mg/mL (ultrasonic;warming)

• Smiles:

  [2H]C([2H])([2H])N[C@@H]1C2=CC=CC=C2[C@H](C3=CC(Cl)=C(C=C3)Cl)CC1.Cl

• Molecular Weight:

  345.71

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Murdoch D, et al. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44(4):604-24.|[3]Koe BK. Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake. J Clin Psychiatry. 1990 Dec;51 Suppl B:13-7.|[4]Xiang X, et, al. Anti-depressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- And TNF-α/TNFR1-mediated NF-κB Activation. ACS Chem Neurosci. 2020 Jul 1.|[5]Lei M, et, al. Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models. Front Cell Neurosci. 2019 Feb 1; 13:24.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1217741-83-7