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ALE-0540

CAT: 0804-HY-124637-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124637-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALE-0540, a nonpeptidic small molecule, is a nerve growth factor receptor antagonist. ALE-0540 inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA with IC50 values of 5.88 μM and 3.72 μM, respectively. ALE-0540 can be used to examine mechanisms leading to the development of agents for the treatment of pain[1].
CAS Number
234779-34-1
UNSPSC
12352005
Hazard Statement
H302+H312-H315-H318-H411
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ale-0540.html
Purity
98.24
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1N(NCCO)C(C2=CC([N+]([O-])=O)=CC3=CC=CC1=C23)=O
Molecular Formula
C14H11N3O5
Molecular Weight
301.25
Precautions
P264-P270-P273-P280-P302+P352-P305+P351+P338-P330-P362+P364-P391-P501
References & Citations
[1]Owolabi JB, et al. Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat. J Pharmacol Exp Ther. 1999 Jun;289 (3) :1271-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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