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Polyphemusin II-Derived Peptide

CAT: 0804-HY-P4810Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P4810Size:1 Each
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Description
Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4[1].
CAS Number
229030-20-0
Product Name Alternative
T140
UNSPSC
12352209
Target
CXCR
Type
Peptides
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/polyphemusin-ii-derived-peptide.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)NC([C@H](CCCNC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC2=CC=C(O)C=C2)NC3=O)=O)=O)=O)NC([C@H](CC4=CC=C(C=CC=C5)C5=C4)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)N6[C@@]3([H])CCC6
Molecular Formula
C90H141N33O18S2
Molecular Weight
2037.42
References & Citations
[1]H Tamamura, et al. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998 Dec 30;253 (3) :877-82.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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