MRT-83 (hydrochloride)

MRT-83 (hydrochloride)

• CAS Number: 1359944-60-7
• UNSPSC Description: MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1].
• Target Antigen: Smo
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mrt-83-hydrochloride.html
• Purity: 99.60
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC(NC(NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)=N)=CC=C3C.Cl
• Molecular Weight: 575.05
• References & Citations: [1]Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported