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Ruscogenin

CAT: 0804-HY-N0496-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0496-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity[1][2].
CAS Number
472-11-7
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
NOD-like Receptor (NLR)
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ruscogenin.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : 4.31 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])C[C@@]1([H])[C@@](CC=C(C[C@@H](O)C5)[C@@]6([C@@H]5O)C)([H])[C@]6([H])CC2
Molecular Formula
C27H42O4
Molecular Weight
430.62
Precautions
H315, H319, H320
References & Citations
[1]Cao G, et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17 (9) . pii: E1418.|[2]Huang YL, et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108 (2) :198-205.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NLRP3

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