STAT1 Recombinant Mouse Monoclonal Antibody [G3-B11-R]

STAT1 Recombinant Mouse Monoclonal Antibody [G3-B11-R]

• Description: STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.
• Product Name Alternative: Signal transducer and activator of transcription 1 91kD antibody CANDF7 antibody DKFZp686B04100 antibody IMD31A antibody IMD31B antibody IMD31C antibody ISGF 3 antibody ISGF-3 antibody OTTHUMP00000163552 antibody OTTHUMP00000165046 antibody OTTHUMP00000165047 antibody OTTHUMP00000205845 antibody Signal transducer and activator of transcription 1 91kDa antibody Signal transducer and activator of transcription 1 antibody Signal transducer and activator of transcription 1, 91kD antibody Signal transducer and activator of transcription 1-alpha/beta antibody STAT 1 antibody Stat1 antibody STAT1_HUMAN antibody STAT91 antibody Transcription factor ISGF 3 components p91 p84 antibody Transcription factor ISGF-3 components p91/p84 antibody
• Abbreviation: STAT1
• CAS Number: 9000-83-3
• Swiss Prot: P42224 Human
• Cellular Locus: Cytoplasm, nucleus
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human STAT1 aa 71-270 / 750.
• Isotype: IgG1
• Clone: G3-B11-R
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: Jurkat cell lysate, A431 cell lysate, HeLa cell lysate, A549 cell lysate, SK-Br-3 cell lysate, SK-MEL-28 cell lysate, MCF7 cell lysate, HT-29 cell lysate, human breast cancer tissue, human spleen tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 87/83 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes