VI-60

CAT: 0804-HY-162228Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-162228Size:1 Each

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Description

VI-60 is a dual, orally active inhibitor of cPLA2 and COX-2, which reveals an anti-inflammtory efficacy through the inhibition of p38 MAPK/cPLA2/COX-2/PGE2 pathway[1].

UNSPSC

12352005

Target

COX; Phospholipase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vi-60.html

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CC/C=C(C(F)(F)F)/OC(C(C)C1=CC=C(C(C2=CC=CC=C2)=O)C=C1)=O

Molecular Formula

C37H43F3O3

Molecular Weight

592.73

References & Citations

[1]Cai N, et al., Discovery of novel NSAID hybrids as cPLA2/COX-2 dual inhibitors alleviating rheumatoid arthritis via inhibiting p38 MAPK pathway. Eur J Med Chem. 2024 Jan 24;267:116176.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

COX-2; Phospholipase A

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