Diclofenac (Sodium) (Standard)
CAT:
804-HY-15037R-01
Size:
100 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Diclofenac (Sodium) (Standard)
- CAS Number: 15307-79-6
- UNSPSC Description: Diclofenac (Sodium) (Standard) is the analytical standard of Diclofenac (Sodium). This product is intended for research and analytical applications. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
- Target Antigen: Apoptosis; COX
- Type: Reference Standards
- Related Pathways: Apoptosis;Immunology/Inflammation
- Field of Research: Inflammation/Immunology; Cancer
- Assay Protocol: https://www.medchemexpress.com/diclofenac-sodium-standard.html
- Smiles: O=C(O[Na])CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl
- Molecular Weight: 318.13
- References & Citations: [1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.|[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.|[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95.
- Shipping Conditions: Room temperature
- Clinical Information: Launched