Diclofenac (Sodium)
CAT:
804-HY-15037-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Diclofenac (Sodium)
- CAS Number: 15307-79-6
- UNSPSC Description: Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
- Target Antigen: Apoptosis; COX
- Type: Reference compound
- Related Pathways: Apoptosis;Immunology/Inflammation
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology; Cancer
- Assay Protocol: https://www.medchemexpress.com/Diclofenac-Sodium.html
- Solubility: DMSO : 125 mg/mL (ultrasonic)|H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(O[Na])CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl
- Molecular Weight: 318.13
- References & Citations: [1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.|[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.|[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95.ACS Infect Dis. 2024 Jul 29.|Arch Microbiol. 2024 Jun 7;206(7):289.|Biotechnol Bioeng. 2021 Sep 3.|Cell Rep Methods. 2023 Oct 23;3(10):100599.|Phys Chem Chem Phys. 2016 Jan 21;18(3):1526-36. |Toxicol Mech Methods. 2019 Nov;29(9):654-664.|bioRxiv. 2024 Apr 7.|Biotechnol Bioeng. 2021 Sep 3.|Chem-Biol Interact. 2021, 109425.|Chemosphere. 2019 Jun;225:378-387. |Eur J Drug Metab Pharmacokinet. 2022 Jun 22.|Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS). 2017 Nov.|Int J Mol Sci. 2022, 23(20), 12066.|J Hazard Mater. 2015 May 30;289:18-27.|J Pharmaceut Biomed. 2021, 114105.|J Phys Chem Solids. 2017 October;109:117-123.|Biotechnol Bioeng. 2021 Sep 3.|Pharm Res. 2022 Aug 24.
- Shipping Conditions: Room Temperature
- Clinical Information: Launched