Otilonium (bromide)

• Description:

  Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome[1][2][3].

• Product Name Alternative:

  Octylonium bromide; SP63

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  MAChR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Otilonium-bromide.html

• Concentration:

  10mM

• Purity:

  99.69

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

• Smiles:

  O=C (OCC[N+] (CC) (CC) C) C1=CC=C (NC (C2=CC=CC=C2OCCCCCCCC) =O) C=C1.[Br-]

• Molecular Formula:

  C29H43BrN2O4

• Molecular Weight:

  563.57

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Battaglia, G., et al., Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment Pharmacol Ther, 1998. 12 (10) : p. 1003-10.|[2]Gandia, L., et al., Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol, 1996. 117 (3) : p. 463-470.|[3]Lindqvist S, et al. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M (3) receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol. 2002 Dec;137 (7) :1134-42.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  26095-59-0