Sodium stibogluconate

• UNSPSC Description:

  Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.

• Target Antigen:

  Parasite; Phosphatase; SHP2

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Purity:

  98.27

• Solubility:

  DMSO : < 1 mg/mL|H2O : 3 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=[Sb](O[C@H]([C@H]1O)C(O)=O)(O[Sb](O[C@@]2([C@@H](CO)O)[H])(O[C@H]([C@H]2O)C(O)=O)=O)O[C@@]1([C@@H](CO)O)[H].O.[Na].[Na].[Na].O.O.O.O.O.O.O.O

• Molecular Weight:

  910.90

• References & Citations:

  [1]Pathak MK, et al. Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. J Immunol. 2001 Sep 15;167(6):3391-7.|[2]Fan K et al. Sodium Stibogluconate Interacts with IL-2 in Anti-Renca Tumor Action via a T Cell-Dependent Mechanism in Connection with Induction of Tumor-Infiltrating Macrophages. J Immunol. 2005 Nov 15;175(10):7003-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  16037-91-5