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Sodium stibogluconate

CAT: 0804-HY-100595-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100595-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
16037-91-5
UNSPSC Description
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.
Target Antigen
Parasite; Phosphatase; SHP2
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.27
Solubility
DMSO : < 1 mg/mL|H2O : 3 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=[Sb](O[C@H]([C@H]1O)C(O)=O)(O[Sb](O[C@@]2([C@@H](CO)O)[H])(O[C@H]([C@H]2O)C(O)=O)=O)O[C@@]1([C@@H](CO)O)[H].O.[Na].[Na].[Na].O.O.O.O.O.O.O.O
Molecular Weight
910.90
References & Citations
[1]Pathak MK, et al. Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. J Immunol. 2001 Sep 15;167(6):3391-7.|[2]Fan K et al. Sodium Stibogluconate Interacts with IL-2 in Anti-Renca Tumor Action via a T Cell-Dependent Mechanism in Connection with Induction of Tumor-Infiltrating Macrophages. J Immunol. 2005 Nov 15;175(10):7003-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Clinical Information
Launched

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