FASN-IN-4

FASN-IN-4

• CAS Number: 1375105-96-6
• UNSPSC Description: FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29)[1]. FASN-IN-4 also inhibits SARS-CoV-2 with an EC50 of 18.6?nM[2].
• Target Antigen: Fatty Acid Synthase (FASN); SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Field of Research: Infection; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/FAS-IN-1.html
• Purity: 99.21
• Solubility: 10 mM in DMSO
• Smiles: O=C1COC2(CCN(S(=O)(C3=CC=C(C4=CC=C5C=CC=NC5=C4)C=C3)=O)CC2)CN1C6CC6
• Molecular Weight: 477.58
• References & Citations: [1]Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.|[2]Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3(11):1466-1475.Cell Biosci. 2022 Sep 16;12(1):158.|Nat Metab. 2021 Sep 27;1-10.|Sci China Life Sci. 2021 May 27;1-21.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported