FASN-IN-4 (tosylate)

FASN-IN-4 (tosylate)

• CAS Number: 2095432-57-6
• UNSPSC Description: FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29)[1]. FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6?nM[2].
• Target Antigen: Fatty Acid Synthase (FASN); SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Field of Research: Infection; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/FAS-IN-1-Tosylate.html
• Purity: 98.55
• Solubility: DMSO : 12.5 mg/mL (ultrasonic)
• Smiles: OS(C1=CC=C(C)C=C1)(=O)=O.O=C2COC3(CCN(S(=O)(C4=CC=C(C5=CC=C6C=CC=NC6=C5)C=C4)=O)CC3)CN2C7CC7
• Molecular Weight: 649.78
• References & Citations: [1]Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.|[2]Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3(11):1466-1475.Sci China Life Sci. 2021 May 27;1-21.|Cell Biosci. 2022 Sep 16;12(1):158.|Nat Metab. 2021 Sep 27;1-10.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported