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Ramosetron (Hydrochloride)

CAT: 0804-HY-B0595-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-B0595-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ramosetron (YM060 free base) Hydrochloride is an orally active 5-HT3 antagonist that improves dysphoria, interference with activity and food avoidance. Ramosetron Hydrochloride is promising for research of irritable bowel syndrome with diarrhea[1][2][3][4].
CAS Number
132907-72-3
Product Name Alternative
YM060
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ramosetron-Hydrochloride.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 32 mg/mL (ultrasonic; warming) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CN(C)C2=C1C=CC=C2)[C@@H](C3)CCC4=C3NC=N4.Cl
Molecular Formula
C17H18ClN3O
Molecular Weight
315.80
Precautions
H302
References & Citations
[1]http://www.drugsupdate.com/generic/view/1111|[2]Yasuda M, et al. 5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells. Br J Pharmacol. 2013 Mar;168 (6) :1388-400.|[3]Kojima SI, et al. Investigation of 5-HT3 receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of PYY-containing endocrine cell. Eur J Pharmacol. 2017 Mar 15;799:196-200. |[4]Fukudo S, et al. Ramosetron Reduces Symptoms of Irritable Bowel Syndrome With Diarrhea and Improves Quality of Life in Women. Gastroenterology. 2016 Feb;150 (2) :358-66.e8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Lactoferrin

Chemical Information

Ramosetron Hydrochloride

Ramosetron hydrochloride is a member of indoles.

CAS Number132907-72-3
PubChem CID107999
IUPAC Name(1-methylindol-3-yl)-[(5R)-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl]methanone;hydrochloride
Molecular FormulaC17H18ClN3O
Molecular Weight315.8
Topological Polar Surface Area50.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity413
SMILES
CN1C=C(C2=CC=CC=C21)C(=O)[C@@H]3CCC4=C(C3)NC=N4.Cl
InChI
InChI=1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1
InChIKey
XIXYTCLDXQRHJO-RFVHGSKJSA-N
Chemical Structure
2D Structure
2D structure of Ramosetron Hydrochloride
CAS: 132907-72-3
CID: 107999
Formula: C17H18ClN3O
MW: 315.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight315.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass315.1138399
Monoisotopic Mass315.1138399
Topological Polar Surface Area50.7 Ų
Heavy Atom Count22
Formal Charge0
Complexity413
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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