4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

• CAS Number: 183322-18-1
• UNSPSC Description: 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline (Compound 11 and 15) is a building block and synthetic intermediate, which can be used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer agents. 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline can also be used to synthesize EGFR inhibitors, including Erlotinib (HY-50896), with antiproliferative activity[1][2].
• Target Antigen: Drug Intermediate
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/4-chloro-6-7-bis-2-methoxyethoxy-quinazoline.html
• Purity: 99.86
• Smiles: ClC1=NC=NC2=C1C=C(OCCOC)C(OCCOC)=C2
• Molecular Weight: 312.75
• References & Citations: [1]Zhang G, et al. Isolation of highly pure erlotinib hydrochloride by recrystallization after nucleophilic substitution of an impurity with piperazine[J]. Research on Chemical Intermediates, 2013, 39(6): 2303-2309.|[2]Knesl P, et al. Improved synthesis of substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib, erlotinib and gefitinib. Molecules. 2006 Apr 10;11(4):286-97.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported