Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free

• Background:

  Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

• Description:

  Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free (IT3-C52W3) is expressed from human 293 cells (HEK293) . It contains AA Phe 31 - Pro 993 & Gly 27 - Asp 718 (Accession # A0A2K5WCD3-1 & A0A2K5WYN9) .

• Specifications:

  Cynomolgus Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB3, has a calculated MW of 113 kDa (ITGAV) and 81.7 kDa (ITGB3) . Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB3 contains no tag but a basic tail at the C-terminus. The protein migrates as 150 kDa (ITGAV) and 90 kDa (ITGB3) when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

• Accession Number:

  A0A2K5WCD3-1 & A0A2K5WYN9

• Expression Region:

  Phe 31 - Pro 993 & Gly 27 - Asp 718

• Host:

  HEK293

• Target:

  Integrin alpha V beta 3

• Conjugation:

  Unconjugated

• Tag:

  C-10xHis | Native

• Source:

  Cynomolgus

• Stability:

  ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

• Endotoxin:

  1.0 EU per μg

• Purity:

  90%

• Format:

  Powder

• Buffer:

  50 mM Tris, 150 mM NaCl, pH8.0

• Additives:

  Trehalose

• Molecular Weight:

  113 kDa & 81.7kDa

• Shipping Conditions:

  RT

• Storage Conditions:

  -20°C

• Package Size:

  100ug*1

• Species:

  Cynomolgus