N-Butanoyl-L-homoserine lactone

• UNSPSC Description:

  N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].

• Target Antigen:

  ADC Linker; Bacterial

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Anti-infection

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/n-butanoyl-l-homoserine-lactone.html

• Purity:

  98.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 20 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  CCCC(N[C@H]1CCOC1=O)=O

• Molecular Weight:

  171.196

• References & Citations:

  [1]Keith Alan Charlton, et al. Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody. US20130045208A1|[2]Zhao M, et al. C4-HSL aptamers for blocking qurom sensing and inhibiting biofilm formation in Pseudomonas aeruginosa and its structure prediction and analysis. PLoS One. 2019 Feb 19;14(2):e0212041.|[3]Feng Sun, et al. Advance of the diversity of bacterial quorum sensing and quorum quenching. National Natural Science Foundation of China. Published online 9 October 2018.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  67605-85-0