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Cis-SU4312

CAT: 0804-HY-100349A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100349A-01Size:1 mg
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Description
Cis-SU4312 ((Z) -SU4312) inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. cis-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively. cis-SU4312 can cross blood brain barrier[1].
CAS Number
90828-16-3
Product Name Alternative
(Z) -SU4312
UNSPSC
12352005
Target
PDGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cis-su4312.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N(C)C)C=C3
Molecular Formula
C17H16N2O
Molecular Weight
264.32
References & Citations
[1]Wei Cui, et al. The anti-cancer agent SU4312 unexpectedly protects against MPP (+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br J Pharmacol. 2013 Mar;168 (5) :1201-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS3847169-01SU4312
A22671-25SU4312 25mg
BUP09083-01(Z) -SU4312
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A22671-10SU4312 10mg
A22671-2SU4312 2mg
A22671-100SU4312 100mg
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