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SU4312

CAT: 0804-HY-100349-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100349-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SU4312 is the racemate of (Z) -SU4312 and (E) -SU4312. (Z) -SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E) -SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively[1].
CAS Number
5812-07-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PDGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/su4312.html
Purity
99.74
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(N(C)C)C=C3
Molecular Formula
C17H16N2O
Molecular Weight
264.32
Precautions
H302, H315, H319, H335
References & Citations
[1]L Sun, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41 (14) :2588-603.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFR; VEGFR2/KDR/Flk-1

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