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Bisantrene

CAT: 0804-HY-100875-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100875-01Size:5 mg
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Description
Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic type II topoisomerases. Bisantrene is a substrate of MDR1[1][2][3][4].
CAS Number
78186-34-2
Product Name Alternative
CL216942
UNSPSC
12352005
Hazard Statement
H302, H400
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Bisantrene.html
Purity
98.06
Solubility
DMSO : 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : < 0.1 mg/mL
Smiles
C12=CC=CC=C1C(/C=N/NC3=NCCN3)=C4C(C=CC=C4)=C2/C=N/NC5=NCCN5
Molecular Formula
C22H22N8
Molecular Weight
398.46
Precautions
H302, H400
References & Citations
[1]Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54 (6) :1036-45.|[2]Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43 (3) :1402-4.|[3]Wang BS, et al. Activation of tumor-cytostatic macrophages with the antitumor agent 9,10-anthracenedicarboxaldehyde bis[ (4,5-dihydro-1H-imidazole-2-yl) hydrazone] dihydrochloride (bisantrene) . Cancer Res. 1984 Jun;44 (6) :2363-7. |[4]Aksentijevich I, et al. Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. Clin Cancer Res. 1996 Jun;2 (6) :973-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Topo II
Citation 01
Anal Chem. 2022 Mar 22;94 (11) :4695-4702.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Mol Cell. 2021 Mar 4;81 (5) :922-939.e9.|Nat Commun. 2021 Apr 12;12 (1) :2183.|Research Square Preprint. 2021 Aug.|Mol Cancer. 2024 Dec 20;23 (1) :275.

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