TAK-632

TAK-632

• CAS Number: 1228591-30-7
• UNSPSC Description: TAK-632 is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAFV600E, BRAFWT, respectively.
• Target Antigen: Aurora Kinase; Raf
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;MAPK/ERK Pathway
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/TAK-632.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(NC1=CC(OC2=CC=C3N=C(NC(C4CC4)=O)SC3=C2C#N)=CC=C1F)CC5=CC=CC(C(F)(F)F)=C5
• Molecular Weight: 554.52
• References & Citations: [1]Okaniwa M, et al. Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives. J Med Chem. 2013 Aug 22;56(16):6478-94.|[2]Nakamura A, et al. Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma. Cancer Res. 2013 Oct 11.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported