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Octyl-α-ketoglutarate

CAT: 0804-HY-114333-01Size: 1 mg (38.71 mM x 100 μL in Methyl Acetate)Dry Ice: NoHazardous: No
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CAT#:0804-HY-114333-01Size:1 mg (38.71 mM x 100 μL in Methyl Acetate)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD[1].
CAS Number
876150-14-0
Product Name Alternative
1-Octyl 2-oxopentanedioate
UNSPSC
12352211
Hazard Statement
H225, H319, H336
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/octyl-α-ketoglutarate.html
Concentration
38.71 mM * 100 μL in Methyl acetate
Purity
99.9
Smiles
O=C(OCCCCCCCC)C(CCC(O)=O)=O
Molecular Formula
C13H22O5
Molecular Weight
258.31
Precautions
H225, H319, H336
References & Citations
[1]MacKenzie ED, et al. Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol. 2007 May;27 (9) :3282-9.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
Phase 1

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