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Uridine triacetate

CAT: 0804-HY-14905-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-14905-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Uridine triacetate (Tri-O-acetyl uridine) is an orally active proagent of Uridine. Uridine triacetate is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate is used for the research of 5-fluorouracil (5-FU) and capecitabine toxicity, or early-onset cardiac or central nervous system (CNS)[2].
CAS Number
4105-38-8
Product Name Alternative
Tri-O-acetyl uridine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/uridine-triacetate.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL|H2O : 10 mg/mL (ultrasonic)
Smiles
O=C1NC(C=CN1[C@H]2[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O2)=O
Molecular Formula
C15H18N2O9
Molecular Weight
370.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Ma WW, et al. Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Cancer. 2017 Jan 1;123 (2) :345-356.|[2]Cada DJ, et al. Uridine Triacetate. Hosp Pharm. 2016 Jun;51 (6) :484-8.|[3]Rolando A G Garcia, et al. Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency. Toxicol Appl Pharmacol. 2018 Aug 15;353:67-73. |[4]Siennah R Miller, et al. Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling. Mol Pharmacol. 2021 Feb;99 (2) :147-162.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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