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Hypusine (dihydrochloride)

CAT: 0804-HY-122039Size: 1 EachDry Ice: NoHazardous: No
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Description
Hypusine dihydrochloride is a natural amino acid found only in the eukaryotic translation initiation factor 5A (eIF-5A) . Hypusine is formed by the transfer of the butylamine portion from spermidine to the ϵ-amino group of a specific lysine residue of eIF-5A precursor and by the hydroxylation at carbon 2 of the incoming 4-aminobutyl moiety[1][2].
CAS Number
82310-93-8
UNSPSC
12352211
Target
Amino Acid Derivatives
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hypusine-dihydrochloride.html
Smiles
O=C([C@H](CCCCNC[C@@H](CCN)O)N)O.Cl.Cl
Molecular Formula
C10H25Cl2N3O3
Molecular Weight
306.23
References & Citations
[1]Park MH, et al. Hypusine, a polyamine-derived amino acid critical for eukaryotic translation. J Biol Chem. 2018 Nov 30;293 (48) :18710-18718.|[2]Beninati S, et al. Tissue transglutaminase expression affects hypusine metabolism in BALB/c 3T3 cells. FEBS Lett. 1998 Oct 16;437 (1-2) :34-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Hypusine dihydrochloride
CAS Number82310-93-8
PubChem CID72941605
IUPAC Name(2S)-2-amino-6-[[(2R)-4-amino-2-hydroxybutyl]amino]hexanoic acid;dihydrochloride
Molecular FormulaC10H25Cl2N3O3
Molecular Weight306.23
Topological Polar Surface Area122
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Heavy Atom Count18
Formal Charge0
Complexity190
SMILES
C(CCNC[C@@H](CCN)O)C[C@@H](C(=O)O)N.Cl.Cl
InChI
InChI=1S/C10H23N3O3.2ClH/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16;;/h8-9,13-14H,1-7,11-12H2,(H,15,16);2*1H/t8-,9+;;/m1../s1
InChIKey
UTSZZUVUESAPQD-BPRGXCPLSA-N
Chemical Structure
2D Structure
2D structure of Hypusine dihydrochloride
CAS: 82310-93-8
CID: 72941605
Formula: C10H25Cl2N3O3
MW: 306.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight306.23
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Exact Mass305.1272971
Monoisotopic Mass305.1272971
Topological Polar Surface Area122 Ų
Heavy Atom Count18
Formal Charge0
Complexity190
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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Alternative Products

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MBS5781709Hypusine
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T32126LHypusine HCl
MBS1568422-01Anti-Hypusine antibody (Hpu24)
GTR18689569-01Hypusine Mouse Monoclonal Antibody
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