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S-HP210

CAT: 0804-HY-146561-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-146561-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S-HP210 is a potent and selective glucocorticoid receptor (GR) with an IC50 value of 1.92 μM for NF-κB transrepression (TR) . S-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. S-HP210 is nontoxic at effective doses against mouse fibroblasts 3T3 cells[1].
UNSPSC
12352005
Target
Glucocorticoid Receptor; NF-κB
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-hp210.html
Purity
98.12
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C[C@@H](C1=CC=CC=C1)NC(C2=CC=C(C=C2)CN3C(C4=C(NC3=S)C=CS4)=O)=O
Molecular Formula
C22H19N3O2S2
Molecular Weight
421.54
References & Citations
[1]Hu X, et al. Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure- and IGN-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem. 2022;237:114382.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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